Biomedical Knowledge Graphs for Drug Discovery: Delta4’s Innovative Approach

Five people gather around a desk, focusing on a computer screen. One person is seated and using the mouse, while the others stand behind observing. Indoor setting with natural light from large windows.

The term “knowledge graph” describes the process of storing data in a graph-structured topology. A graph database consists of three main elements: nodes, edges, and properties. Nodes symbolize instances or entities, such as proteins, diseases, or tissues. Edges, otherwise known as relationships, provide a contextual connection between nodes. Properties, on the other hand, enrich both […]

The Path to New Therapies for Focal Segmental Glomerulosclerosis (FSGS)

Hands holding a paper cutout of a red kidney on a light blue background.

Developing new treatments for complex diseases presents a myriad of challenges, ranging from understanding the disease’s mechanisms to ensuring the safety and effectiveness of proposed therapies. At Delta4, we’re passionately pursuing new treatments for Focal Segmental Glomerulosclerosis (FSGS). Leveraging our in-silico platform, Hyper-C, we’ve been able to identify new potential therapeutic options for FSGS. This […]

Pioneering the Future of Nephrotic Syndrome Research with ARREST-NEPHROSIS

A doctor holding up a tablet with an image of a kidney.

Nephrotic Syndrome affects millions globally, presenting a significant health burden with its hallmark symptoms of severe proteinuria and edema. The quest for advanced treatments underscores the crucial role of biobanks and registries, which are instrumental in propelling medical research and innovation. At the forefront of this effort is ARREST-NEPHROSIS, an Austrian registry that exemplifies how […]

What to Expect From The Pharmaceutical Industry In 2024

Two lab technicians wearing protective gear work in a laboratory within the pharmaceutical industry; one is using a touchscreen monitor, while the other sits at a desk in the background.

As we step into 2024, the pharmaceutical industry stands at the cusp of remarkable advancements and significant transformations. This year promises to be a pivotal one, with key trends, innovations, and challenges shaping the future of healthcare and medicine and defining the pharmaceutical landscape. Key Pharmaceutical Industry Trends to Watch in 2024 Let’s explore the […]

Digital Health Envision Summit

Digital Health Envision

We are delighted to announce that Dr. Klaus Kratochwill, CSO, and Dr. Paul Perco, Computational Biology Lead of Delta4, are looking forward to attending the prestigious 2023 Digital Health Envision Summit to be held in London, UK.  The summit, renowned for being a hub of innovation in healthcare and neurology, aligns seamlessly with Delta4’s mission […]

Case Study: Unravelling the Multifaceted Potential of Iguratimod with Delta4’s Hyper-C Platform

Diving deep into the realms of computational drug repurposing

Diving deep into the realms of computational drug repurposing, Delta4 leveraged its state-of-the-art Hyper-C platform with an ambitious objective: to comprehensively understand and broaden the applications of the anti-inflammatory compound iguratimod.  At the heart of this project was the creation of a molecular Mechanism of Action (MoA) model. This intricate model was meticulously constructed around […]

Delta4 at RExPO: Pushing the Boundaries of Drug Repurposing

RexPo23

We are thrilled to announce that Delta4 will be in attendance at this year’s RExPO23, a landmark event in the realm of Systems Medicine, Artificial Intelligence, and Drug Repurposing. As pioneers in AI-enabled drug repurposing and indication expansion, our presence underscores our commitment to fostering global collaborations and accelerating advancements in this transformative field. Dr. […]

Reactome Spotlights Delta4’s Computational Drug Repositioning of Clopidogrel for FSGS

Reactome

We are honored to announce that our publication on the computational drug repositioning of clopidogrel has been highlighted in the Reactome research spotlight. This notable recognition from a reputable bioinformatics database underscores the potential of our innovative approach in addressing Focal Segmental Glomerulosclerosis (FSGS), a severe glomerular lesion associated with nephrotic syndrome and a high […]

Delta4’s Innovation Shines: OntoloViz Article Published in Bioinformatics Advances Journal

OntoloViz

We are thrilled to announce that our journal article, titled “OntoloViz: a GUI for interactive visualization of ranked disease or drug lists using the MeSH and ATC ontologies,” has been published in the esteemed Bioinformatics Advances Journal. This publication accentuates Delta4’s continuous endeavor to push the boundaries of TechBio innovation, bridging computational power and biological […]